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Enzyme Research Laboratories human fiia
Human Fiia, supplied by Enzyme Research Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+fiia/fiia/us12091399-175-3-14
Average 90 stars, based on 1 article reviews
human fiia - by Bioz Stars, 2026-10
90/100 stars

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Article Title: Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
Article Snippet: Afterwards 0.25 mM fluorogenic substrate H-Pro-Phe-Arg-AMC (11295 from Bachem) was added to the mixture and measurements were performed in a kinetic interval every 2nd minute for 12 min using a Spectramax M5 (Molecular Devices) with the following settings of the wavelength excitation of 350 nm and wavelength emission of 450 nm.

Article Title: Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.
Article Snippet: A series of thiophene-containing non-amidine factor Xa inhibitors is described.. Simple methyl-substituted thiophene analogs were relatively weak inhibitors.. However, introduction of hydrophilic substituents at C-4 or C-5 of the thiophene afforded inhibitors with low nanomolar potency.

Article Title: Phenyltetrazole derivatives as plasma kallikrein inhibitors
Article Snippet: Evaluation of the Inhibition of FIIa (Ki) Human FIIa (44.6 nM or 5 U/mL; Enzyme Research Laboratories) was incubated at 24° C. with 0.5 mM chromogenic Substrate S2238 (Chromogenix) and various concentrations of the test compound in assay buffer.

Inhibition:

Article Title: Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
Article Snippet: Measurements are performed in a kinetic interval every 2nd minute for 16 min using a Spectramax M5 (Molecular Devices) measuring the optical absorbance at 405 nm. .. Evaluation of the Inhibition of FIIa (Ki) Human FIIa (44.6 nM or 5 U/mL; Enzyme Research Laboratories) is incubated at 24° C. with 0.5 mM chromogenic Substrate S2238 (Chromogenix) and various concentrations of the test compound in assay buffer. .. Measurements are performed in a kinetic interval every 2nd minute for 16 min using a Spectramax M5 (Molecular Devices) measuring the optical absorbance at 405 nm.

Article Title: Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
Article Snippet: Measurements are performed in a kinetic interval every 2nd minute for 16 min using a Spectramax M5 (Molecular Devices) measuring the optical absorbance at 405 nm. .. Evaluation of the Inhibition of FIIa (Ki) Human FIIa (44.6 nM or 5 U/mL; Enzyme Research Laboratories) is incubated at 24° C. with 0.5 mM chromogenic Substrate S2238 (Chromogenix) and various concentrations of the test compound in assay buffer. .. Measurements are performed in a kinetic interval every 2nd minute for 16 min using a Spectramax M5 (Molecular Devices) measuring the optical absorbance at 405 nm.

Incubation:

Article Title: Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
Article Snippet: Measurements are performed in a kinetic interval every 2nd minute for 16 min using a Spectramax M5 (Molecular Devices) measuring the optical absorbance at 405 nm. .. Evaluation of the Inhibition of FIIa (Ki) Human FIIa (44.6 nM or 5 U/mL; Enzyme Research Laboratories) is incubated at 24° C. with 0.5 mM chromogenic Substrate S2238 (Chromogenix) and various concentrations of the test compound in assay buffer. .. Measurements are performed in a kinetic interval every 2nd minute for 16 min using a Spectramax M5 (Molecular Devices) measuring the optical absorbance at 405 nm.

Article Title: Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors
Article Snippet: Measurements are performed in a kinetic interval every 2nd minute for 16 min using a Spectramax M5 (Molecular Devices) measuring the optical absorbance at 405 nm. .. Evaluation of the Inhibition of FIIa (Ki) Human FIIa (44.6 nM or 5 U/mL; Enzyme Research Laboratories) is incubated at 24° C. with 0.5 mM chromogenic Substrate S2238 (Chromogenix) and various concentrations of the test compound in assay buffer. .. Measurements are performed in a kinetic interval every 2nd minute for 16 min using a Spectramax M5 (Molecular Devices) measuring the optical absorbance at 405 nm.



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